The Bishop Laboratory
The Bishop Laboratory uses molecular biology and bioinformatics techniques to identify and understand the mechanisms of damage survival and response. People who inherit a deficiency in damage response are predisposed to develop cancer, usually as children or young adolescents. Further, most cancer treatments are based on damaging cancer cells, so understanding why a chemotherapy works, and for which patients, should lead to more effective (targeted) and less toxic treatments that will increase the cure rate and improve quality of life for cancer survivors.
My research focus for the last 20 years has been on DNA repair and DNA damage response. For this my lab uses a variety of model systems, including in vivo mouse models and tissue culture systems. DNA damage response and repair is central to normal development and when aberrant, developmental defects, aging phenotypes and cancer ensue. Our work reflects these various aspects of DNA damage response and DNA repair biology, often taking what might be termed a systems biology approach.
Meet the lab
The Bishop lab was founded in 2006 as part of the Greehey Children’s Cancer Research Institute. We are an interdisciplinary team of bench scientists and bioinformaticians. Learn more about our lab from the members page. To learn about our available opportunities in the Bishop lab, please visit our contact page.