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Current Research Funding

SU2C-CRUK Pediatric Cancer New Discoveries ChallengeTargeting R-loop stability in Ewing sarcomaTo determine the therapeutic utility of targeting R-loop stabilizing mechanisms in Ewing sarcoma.Bishop10/2020 – 09/2022
NIH/NCI R01 CA241554Dysregulated transcription processes in Ewing sarcomaTo determine the consequences of dysregulated transcription regulation in Ewing sarcoma.Bishop05/2020 – 04/2025
CPRIT RP170345UTHSCSA Cancer Research Training ProgramResearch Training Award supports for pre-doctoral, post-doctoral trainees, and summer (undergraduate) students, as part of a comprehensive training program covering all aspects cancer research.Oyajobi, Colaborator: Bishop12/01/16 – 11/20/21
The Andrew McDonough B+ Foundation #614252: Research GrantTargeting RNA processing defects of Ewing sarcomaTo follow up on initial validations of a previously conducted RNAi screen that identified splicing components as synthetic lethal target in Ewing sarcoma. The aim is to then evaluate splicing inhibitors that have the same effect as RNAi depletion of splicing genes and if a therapeutic window exists that can that suggests these inhibitors can be used in the treatment of Ewing sarcoma.Bishop01/2019 – 12/2020
IIMS/GCCRI Pilot fundsTargeting the transcription dysregulation of Ewing sarcomaTo validate an RNAi screen for synthetic lethal viability in Ewing sarcoma to identify determinants of transcription regulation and therapeutic targets that can be used in the treatment of Ewing sarcoma.Bishop05/2017 – 04/2019
(NCE to 04/2020)
GCCRI pilot experiment supportMetabolomics in ATM inhibited cellsIsotope tracing metabolomics experiment in cells +/- ATM inhibitor for glucose and glutamine utilization.Bishop 09/2019 – 08/2020
MERCK EMD SeranoAssessing the accumulation of R-loops in cancer as an indication of sensitivity to RNA splicing inhibitionTo identify whether high R-loops indicate splicing defects in cancers and sensitivity to splicing inhibitors.Bishop10/2019 – 10/2021

Ongoing Fellowships to Trainees

Greehey Graduate Predoctoral Fellowship Predoctoral FellowshipEpigenetic changes in Ewing Sarcoma.MillerBishop09/2020 – 09/2021
Mays Cancer Center Fellowship Predoctoral FellowshipEwing Sarcoma relies on Endogenous Cysteine and Glutamine for Antioxidant Response.KandaBishop08/2020 – 07/2022
CPRIT Training Grant RP170345 Predoctoral FellowshipEvaluate replication stress in Ewing sarcoma.MukhopadhyayBishop10/2020 – 09/2021
AACR-AstraZeneca START fellowshipIdentifying Modifiers of PARP1 Inhibitor Sensitivity in BRCA-like TumorsGorthiBishop08/2018 – 07/2021
CDMRP PRCRP Horizon Fellowship CA181177Transcription, R-Loops, and RNA Splicing in Ewing SarcomaLawrenceBishop08/2019 – 07/2021

Completed Research Funding

CPRIT RP150445: IIRACCAEwing’s sarcoma, a homologous recombination defective diseaseBishop03/2015 – 02/2019
(NCE to 08/2019) 
Najim Foundation and GCCRI funds AwardTo conduct a siRNA viability screen in Ewing sarcoma cells to identify new targets for treatment.Bishop07/2015 – 06/2016
Hyundai Hope on Wheels Hope Grant AwardHomologous recombination defect in malignant myeloid diseases in childrenBishop09/2012 – 08/2014
San Antonio Area Foundation 152711 Biomedical Research GrantTargeting altered nucleotide pool to treat cancer cellsBishop 05/2012 – 04/2013
NIH NCI 1R01CA179120miRNAs: Safe and effective therapeutic adjuvants for treating drug resistant TNBCRao, Co-I: Bishop02/2015 – 01/2020
NIH/NCI R01CA152063Improving etoposide treatment of Ewing’s sarcomaBishop09/2011 – 07/2016
(NCE to 07/2018)
Helen Freeborn Kerr Charitable Foundation AwardIdentifying mechanisms involved in cancer development and novel means to prevent cancer formingBishop09/2011 – 04/2012
Max and Minnie Tomerlin Voelcker Fund Young Investigator AwardDetermining cisplatin survival factors to augment ovarian cancer treatmentBishop07/2010 – 06/2013
ACS RSG-10-049-01-DMC Research GrantIntegration of the Jun N-terminal Kinase and p53 signaling pathwaysMcEwan, Co-I: Bishop01/2010 – 12/2013
NIH/NIEHS R15ES019128Comparing and contrasting the biology of damage survival at a genomic levelBishop05/2010 – 10/2013
ACS 122295 PilotUsing conditional mutants to investigate recombinationBishop08/2005 – 08/2006
NIH/NIEHS K22 ES-02-006A screen for damage response using recombinationBishop09/2004 – 09/2007
(NCE to 05/2010)

Completed Fellowship Funding

NCATS TL1TR002647 Postdoctoral fellowshipGorthiBishop and Chen07/2018 – 06/2019
NCATS TL1TR002647 Predoctoral Training FellowshipLawrenceBishop07/2018 – 06/2020
NIH/NCI T32CA148724 Postdoctoral fellowshipGorthiBishop and Chen09/2015 – 08/2017
Greehey Graduate Predoctoral FellowshipSyboutsBishop09/2015 – 08/2016
CPRIT Training Grant Postdoctoral FellowshipRomeroBishop09/2015 – 08/2016
DoD CDMRP BCRP Postdoctoral FellowshipZanotto-FilhoBishop12/2013 – 11/2016
Greehey Graduate Predoctoral FellowshipChavez-SantoscoBishop09/2013 – 08/2014
NIH/NCI T32CA148724 Predoctoral FellowshipTonapiBishop07/2013 – 06/2015
CPRIT Training Grant Predoctoral FellowshipGorthiBishop10/2012 – 09/2013
Greehey Graduate Predoctoral FellowshipGorthiBishop09/2011 – 08/2012
DoD CDMRP BCRP BC093931 Predoctoral FellowshipKariaBishop01/2010 – 12/2012
NIH/NIA 5T32AG021890 Predoctoral FellowshipBrownBishop05/2007 – 04/2012
NIH/NIGMS F32 GM19147 Postdoctoral FellowshipBishop07/1997 – 06/2000
Medical Research Council UK Predoctoral FellowshipBishop09/1993 – 08/1996
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